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FLASH GENE
Symbol CSE1L contributors: mct - updated : 23-08-2015
HGNC name CSE1 chromosome segregation 1-like (yeast)
HGNC id 2431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a nuclear localization signal (NLS)
HOMOLOGY
interspecies homolog to yeast chromosome segregation gene 1 (CSE1)
Homologene
FAMILY CSEL family
CATEGORY regulatory , transport
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
text shuttles between the nucleus and the cytoplasm
basic FUNCTION
  • involved in the cell cycle of mammalian cells and in apoptosis
  • transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
  • associating with a subset of p53 target promoters, cooperating with p53 to activate transcription of these genes by altering histone modification, specifically histone H3 lysine 27
  • regulates the secretion of colorectal cells and may rgulate the metastasis of colorectal cancer
  • may be involved in the "early" and "late" metastasis of tumor cells in tumorigenesis
  • required for the expression of genes promoting invasion and metastasis
  • plays roles in the regulation of the HR activity and in chromosome stability, and is likely responsible for controlling the HR activity by directly interacting with RAD51
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    cofactor of p53
    a component
    INTERACTION
    DNA binding to chromatin
    RNA
    small molecule
    protein
  • binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1
  • is a negative regulator of CFTR-dependent fluid secretion
  • CSE1L associates with RAD51 in human cells, and negatively regulates the nuclear protein level of RAD51 under normal conditions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer (pMID: 23948303)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • urinary CSE1L deserves further evaluation for the screening of bladder cancer
  • immunohistochemical staining of nuclear CSE1L may be useful for the prognosis of bladder urothelial carcinomas
  • Therapy target
    ANIMAL & CELL MODELS