basic FUNCTION
| involved in the cell cycle of mammalian cells and in apoptosis |
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transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm |
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associating with a subset of p53 target promoters, cooperating with p53 to activate transcription of these genes by altering histone modification, specifically histone H3 lysine 27 |
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regulates the secretion of colorectal cells and may rgulate the metastasis of colorectal cancer |
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may be involved in the "early" and "late" metastasis of tumor cells in tumorigenesis |
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required for the expression of genes promoting invasion and metastasis |
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plays roles in the regulation of the HR activity and in chromosome stability, and is likely responsible for controlling the HR activity by directly interacting with RAD51 |