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FLASH GENE
Symbol LMAN2 contributors: mct - updated : 12-02-2019
HGNC name lectin, mannose-binding 2
HGNC id 16986
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal sequence
  • one leguminous lectin-like domain, in its extracellular region
  • a lectin-type carbohydrate recognition domain
  • a C-terminal transmembrane domain, wirh tetrapeptide KRFY
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Lman2_predicted
    ortholog to murine Lman2
    intraspecies homolog to LMAN2L
    Homologene
    FAMILY family of leguminous type (L-type) lectins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 1 membrane protein
  • localizes to the Golgi apparatus and cycles early in the secretory pathway
  • localizes mainly to the ER and Golgi
  • basic FUNCTION
  • play a role as an intracellular lectin in the early secretory pathway
  • may retrieve misfolded glycoproteins back to the ER that have inadvertently escaped quality control in the ER
  • intracellular lectin that cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoprotein
  • new role in the quality control of secretory proteins
  • shedding target and plays a role in phagocytosis in a shedding-dependent manner
  • regulates multiple steps of intracellular transport, including retrograde transport of immature glycoproteins from the Golgi to ER and phagocytosis of pathogens from the extracellular space to the endosome
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
  • Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively
  • a component
  • LMAN2/SERPINA1 complex localized to Golgi and endoplasmic reticulum (ER)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, other,
  • two Ca2+ binding
  • interacts with N-acetyl D-galactosamine and high-mannose type glycans
  • protein
  • interaction between LMAN2 and HSPA5, that is carbohydrate-independent
  • bound exclusively to the high-mannose form of SERPINA1 (function of LMAN2 in post-ER quality control of SERPINA1)
  • ADAM17 participates at least in part in the shedding of LMAN2
  • GUCY2C is the first identified receptor client of the lectin chaperone vesicular integral membrane protein, LMAN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    tuberculosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene low expression of heterozygote genotype A/0 may be associated with protection against tuberculosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS