basic FUNCTION
| involved in adhesion of platelets and megakaryocytic cells to vascular endothelial cells |
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may play a predominant role in inducing cytotoxicity via an interaction with PVR and PVRL2 |
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contributes to NK-mediated lysis of tumor cells |
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transduces activating signals resulting in tyrosine phosphorylation of CD226 itself |
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playing an important role in maturation of the megakaryocytes in combination with ITGAL |
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binding of PVR with CD226 negatively regulates osteoclast formation |
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serves to extend the range of target cells that can activate CD8 T cell and NK cells and, hence, may be essential for immunosurveillance against tumors and/or viruses |
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contributes to tumor immune surveillance and plays a crucial role in NK cell-mediated recognition of several types of tumors, including ovarian carcinoma |
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having importance in facilitating activation signals received by NK cells in natural and cytokine-driven responses to tumor metastases |
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involved in T cell differentiation, activation, and cytotoxicity |
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involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus |