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FLASH GENE
Symbol IGSF11 contributors: - updated : 15-02-2006
HGNC name immunoglobulin superfamily, member 11
HGNC id 16669
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • three extracellular N-linked glycosylation sites
  • a V-type Ig-like domain
  • a C2-type Ig-like domain
  • a C-terminal PDZ-interacting motif
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Igsf11_predicted
    ortholog to murine Igsf11
    intraspecies homolog to CXADR
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play a role in the development or function of the central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    frequently, in intestinal-type gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene good candidate of cancer-testis antigen
    Marker
    Therapy target target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas
    ANIMAL & CELL MODELS