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FLASH GENE
Symbol PHC3 contributors: mct/npt - updated : 09-03-2009
HGNC name polyhomeotic homolog 3 (Drosophila)
HGNC id 15682
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SAM (sterile alpha motif) domain
    • HOMOLOGY
    Homologene
    FAMILY
  • polycomb gene family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text E2F6 showed nuclear colocalization in a punctate pattern that resembled the binding of polycomb bodies to heterochromatin (Deshpande 2007)
    basic FUNCTION
  • nuclear proteins that are constituents of evolutionarily conserved protein complexes designated class II PcG complexes (Isono 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the human polycomb complex PRC-H (Deshpande 2007)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with both PRC-H complex components and with the transcription factor E2F6 (Deshpande 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in primary osteosarcoma tumors ( loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0)(Deshpande 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS