basic FUNCTION
| having calcium ion binding activity |
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has the capacity to form a complex with the SH3 domains of the adapter proteins CRK and GRB2, which may link REPS1 to an EGF-responsive tyrosine kinase |
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may coordinate the cellular actions of activated EGF receptors and Ral-GTPases |
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engaged in EGFR signaling and undergoes phosphorylation upon EGF stimulation |
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conserved EH domain-containing protein primarily associated with endocytosis and vesicle transport |
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REPS1, and RALBP1 are present early during embryonic development, but they are active only at the end of gastrulation |
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later in development, REPS1 is required for the normal function of the ectodermic cell, and its targeting into the plasma membrane affects the stability of the ectoderm |