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FLASH GENE
Symbol DPP7 contributors: - updated : 17-03-2004
HGNC name dipeptidylpeptidase 7
HGNC id 14892
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
peptidase S28 motif
secondary structure N-glycosylated protein
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Dpp7
intraspecies homolog to PCP
Homologene
FAMILY DASH protein
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,lysosome
intracellular,cytoplasm,cytosolic,vesicle
basic FUNCTION
  • prolylcarboxypeptidase activity
  • plays an important role in the degradation of collagen and some oligopeptides, releasing a N-terminal dipeptide
  • active at both acidic and neutral pH
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by Lys-thiazolidide and Lys-piperidide
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS