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FLASH GENE
Symbol PPP1R2 contributors: mct - updated : 21-09-2012
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 2
HGNC id 9288
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ppp1r2
homolog to C.elegans Y32H12A.4
intraspecies homolog to IPP-2
Homologene
FAMILY protein phosphatase inhibitor 2 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
text
  • found concentrated in cilia of epithelial cells, and was localized to cilia early in the process of formation, prior to the full acetylation of microtubules
    • basic FUNCTION
  • inhibitor subunit of protein phosphatase 1, involved in mammalian cell division
  • acts to enhance Aurora B by inhibiting specific PPP1CA holoenzymes that dephosphorylate Aurora B substrates necessary for chromosome segregation and cytokinesis
  • localizes to the primary cilium where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation
  • as a multifunctional protein, may link cell cycle progression to structure and stability of the primary cilium
  • major serine/threonine-phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting proteins (PIPs), responsible for targeting PP1 to a specific cellular location, specifying its substrate or regulating its action
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    energy pathways
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein catalytic subunit of PP1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal, lung, gastric ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS