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FLASH GENE
Symbol STAU1 contributors: mct/npt - updated : 23-08-2016
HGNC name staufen, RNA binding protein, homolog 1 (Drosophila)
HGNC id 11370
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four double-stranded RNA-binding domain (RBD1-4)
  • a nuclear localization signal
  • HOMOLOGY
    interspecies homolog to Drosophila Staufen
    Homologene
    FAMILY
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,microfilament
    intracellular,nucleus,nucleolus
    text
  • mainly localized to the rough endoplasmic reticulum, and in the nucleus/nucleolus, suggesting nucleocytoplasmic shuttling or other functions
  • basic FUNCTION
  • involved in mRNA transport and localization
  • targeting of RNA to its site of translation
  • playing a putative role in the regulation of translation
  • involved in RNA localization in polarized neurons
  • influences the expression of a wide variety of physiologic transcripts and metabolic pathways
  • crucial for synapse development but not critical for normal behavioral function
  • implicated in dendritic RNA localization in neurons, translational control, and mRNA decay
  • RNA-binding protein involved in transport, localization, decay, and translational control of mRNA
  • important for processing and/or transporting in dendrites mRNAs that are critical in regulation of synaptic strength and maintenance of functional connectivity changes underlying hippocampus-dependent learning and memory
  • thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1)
  • recruited to stress granules upon induction of endoplasmic reticulum or oxidative stress as well in stress granules induced by translation initiation blockers
  • involved in recovery from stress by stabilizing polysomes, thus helping stress granule dissolution
  • relevant role in the influenza A virus replication
  • critical protein regulating the anterior to posterior distribution of some mRNAs, in oocyte development
  • STAU1 self-associates in mRNPs via its multiple functional domains that can select mRNAs to be transported and establish protein-protein interaction
  • required for protein synthesis-dependent long-term potentiation (L-LTP) in hippocampal pyramidal cells
  • role of STAU1-dependent mRNA regulation in physiological and morphological changes underlying long-term synaptic plasticity in pyramidal cells
  • DVL2 has an inhibitory role in myogenesis and STAU1 coordinates myogenesis through the regulation of DVL2 mRNA
  • potential role for STAU1 in viral replication
  • double-stranded RNA binding protein involved in diverse gene expression pathways
  • biological role for STAU1-mediated mRNA decay in adipogenesis
  • novel function for STAU1 in splicing regulation
  • TINCR together with STAU1 is required for epidermal differentiation
  • role for TINCR as an epithelial-specific guide for targeting the STAU1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue
  • regulates translation of transcription-regulatory proteins
  • STAU1 identifies a wide spectrum of cellular target mRNAs to control their localization, expression and fate
  • RNA-binding protein involved in the post-transcriptional regulation of gene expression
  • participates potentially in a mechanism of post-transcriptional regulation of gene expression that is linked to cell cycle progression in cancer cells
  • highly expressed during early stages of differentiation/development and it can impair differentiation by regulating MYC, thereby highlighting the multifunctional role of STAU1 in skeletal muscle cells
  • splicing regulator and may likely act as a disease modifier in DM1 (Myotonic dystrophy type 1)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • components of RNPs that travel along microtubules from the soma to distant dendritic sites
  • TARDBP is physically associated with FMR1 and Staufen (STAU1) to form a functional complex, and depletion of TARDBP/FMR1/STAU1 sensitizes cells to apoptosis and DNA damages
  • INTERACTION
    DNA
    RNA binding to double stranded RNA
    small molecule
    protein
  • linked to nucleocytoplasmic RNA-binding protein nucleolin in an RNA-dependent manner
  • binds to a complex structure within the ARF1 3'-UTR
  • binds to 3prime untranslated region (UTR) of DVL2 mRNA, and after induction of myogenic differentiation, this association was decreased
  • TARDBP is physically associated with fragile X mental retardation protein (FMR1) and Staufen (STAU1) to form a functional complex
  • TARDBP/FMR1/STAU1 specifically binds to the 3prime-UTR of SIRT1 mRNA (
  • STAU2 interacts directly with UPF1 to reduce the half-life of STAU1-mediated mRNA decay targets that form an STAU1-binding site by either intramolecular or intermolecular base-pairing
  • TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of gastric cancer (GC)cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    rescues alternative splicing of two key pre-mRNAs known to be aberrantly spliced in DM1 (Myotonic dystrophy 1), suggesting its increased expression represents an adaptive response to the pathology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neuromuscular  
    may positively modulate the complex Myotonic dystrophy 1 phenotype, thereby revealing its potential as a therapeutic target
    ANIMAL & CELL MODELS