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FLASH GENE
Symbol RIOK3 contributors: mct/npt/pgu - updated : 25-08-2013
HGNC name RIO kinase 3 (yeast)
HGNC id 11451
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RIO-like kinase domain
  • rich in glutamine, aspartic acid, serine and threonine residues
  • HOMOLOGY
    interspecies homolog to Aspergillus nidulans extragenic suppressor gene of the heat-sensitive bimD6 mutation
    homolog to murine Riok3
    homolog to rattus LOC361293
    Homologene
    FAMILY
  • RIO kinase family
  • protein kinase superfamily
  • RIO-type Ser/Thr kinase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • protein kinase activity
  • involved in chromosome condensation and segregation
  • promotes cell migration through the activation of AKT1
  • mediator of pancreatic ductal cell migration and invasion
  • is a polyubiquitin binder
  • negatively regulates NF-kappaB signaling pathway activated by TNFalpha dependent on its kinase activity and NF-kappaB signaling pathway activated by caspase-10 independent of its kinase activity
  • cytoplasmic protein that does not seem to shuttle between nucleus and cytoplasm via a XPO1-dependent mechanism
  • is potentially a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells, required for normal processing of the 21S pre-rRNA
  • fFunctionally, RIOK3 acts as a SUFU-dependent positive regulator of HH signaling
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacted with caspase-10 (interaction was mediated by the RIO domain of RIOK3 and each death effector domain of CASP10)
  • is a novel modulator of SUFU subcellular distribution
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    alters cytoskeletal architecture as well as promotes pancreatic ductal cell migration and invasion
    tumoral     --over  
    in metastatic Head and Neck cancers compared with nonrecurrent tumors
    constitutional     --over  
    repressed NF-kappaB activity in a manner similar to optineurin, while siRNAs directed against ZFAND6 and RIOK3 also reduced NF-kappaB activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target point to the Rho signaling pathway as a focus for future cancer drug discovery efforts
    ANIMAL & CELL MODELS