protein
| with AURKA (enhancing AURKA activity during mitosis) |
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interacts with the spindle assembly factors dynein and HMMR (like TPX2, HMMR expression is up-regulated during mitosis) |
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TPX2 binding with AURKA decreases the size and accessibility of a hydrophobic pocket, adjacent to the ATP site, to inhibitors |
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KIF11 interacts with the spindle assembly factor TPX2 (this interaction was required for kinetochore fiber formation and contributed to KIF11 localization to spindle microtubules but not spindle poles) |
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PKD1 cytoplasmic tail associates with the transcription factors TPX2 and STAT6 |
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constitutive control of TPX2 on H4K16ac levels, with potential implications for DNA damage response |
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TPX2 is a multifunctional mitotic spindle assembly factor that in mammalian cells localizes and regulates mitotic motor protein KIF11, and TPX2 regulates neuronal morphology through KIF11 interaction |
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BCL2L10 is a binding partner of TPX2 and a new regulator of the complex controlling the organization of microtubules and microtubule organizing center (MTOC) biogenesis in meiotic spindle assembly |
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RAN-dependent TPX2 activation promotes acentrosomal MT nucleation in neurons |
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TPX2 promotes the proliferation and migration of human Ovarian cancer cells by regulating PLK1 expression |
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novel function of ADD1 in maintaining spindle pole integrity through its interaction with TPX2 |
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TPX2/AURKA plays a previously unrecognized role in DNA damage repair and replication fork stability by counteracting TP53BP1 function |
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well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of AURKA |