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FLASH GENE
Symbol HSPH1 contributors: mct/npt - updated : 19-10-2015
HGNC name heat shock 105kDa/110kDa protein 1
HGNC id 16969
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • subgroup of the HSP70 family, HSP105/110
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • having ATP binding activity
  • suppress H2O2-induced apoptosis by suppression of p38 MAPK signaling, one of the essential pathways for apoptosis
  • thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSPA5 (Park 2009)
  • may play an important role in the refolding of denatured proteins and protection against stress-induced cell death in mammalian cells
  • important element of the Hsp70 chaperone machinery for refolding of denatured proteins and protection against stress-induced cell death in mammalian cells
  • has a primary role promoting CFTR quality control at an earlier stage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with glycogen synthase kinase-3 (GSK3B), a promoter of ER stress-induced apoptosis, and HSPA5, a key component of the unfolded protein response (promotes ER stress-induced caspase-3 activation)(Meares 2008)
  • HSPH1 suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of HSPA4
  • HSPH1 is required for WNT signaling, since depletion of HSPH1 compromises CTNNB1 accumulation and target gene transcription upon WNT stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon and pancreatic adenocarcinoma
    tumoral     --over  
    in skin cancers including extramammary Paget disease (EMPD), and cutaneous squamous cell carcinoma (SCC)
    tumoral     --over  
    in melanoma cell lines (Muchemwa 2008)
    tumoral     --over  
    is a prognostic biomarker that correlates with poor overall survival in breast cancer patients as well as melanoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS