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FLASH GENE
Symbol CEP104 contributors: mct - updated : 09-12-2015
HGNC name centrosomal protein 104
HGNC id 24866
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two glycosylation sites
  • three hydrophobic domains
  • four cysteine-rich motifs (C-X2-C-X16-20-C-X5-11)
  • a tubulin-binding TOG (tumor overexpressed gene) domain
  • and a novel C2HC zinc finger array
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • membrane-associated
  • localizes on the distal ends of both centrioles of nondividing cells until the mother centriole forms a cilium and then localizes at the tip of the elongating cilium
  • moves from the mother centriole to the tip of the primary cilium during ciliogenesis
  • localizes on both mother and daughter centrioles in non-ciliated retinal pigment epithelial (RPE1) cells but only on the daughter centriole in ciliated cells
  • basic FUNCTION
  • may be isolated as a soluble or membrane-associated assembly that serves as a structural and functional homologue of the extracellular domain (ECD) of GLRA1
  • likely acts early during cilia formation by regulating the conversion of the mother centriole into the cilia basal body
  • key player in the regulation of cilia formation, and is a novel tubulin-binding protein
  • is a key factor involved in cilia formation and length regulation that rides on the ends of elongating and shrinking cilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of CEP104 with CCP110, CEP97, end-binding (EB) protein, and tubulin
  • NEK1 competes for binding to CEP104 with the distal centriole-capping protein CCP110
  • cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • membrane-associated
  • localizes on the distal ends of both centrioles of nondividing cells until the mother centriole forms a cilium and then localizes at the tip of the elongating cilium
  • moves from the mother centriole to the tip of the primary cilium during ciliogenesis
  • localizes on both mother and daughter centrioles in non-ciliated retinal pigment epithelial (RPE1) cells but only on the daughter centriole in ciliated cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JBTS25
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS