Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC39A9 contributors: mct - updated : 08-09-2021
HGNC name solute carrier family 39 (zinc transporter), member 9
HGNC id 20182
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • SLC39A family of zinc transporters
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • ZIP9 functions likely to regulate zinc homeostasis in the secretory pathway without significantly altering cytosolic zinc homeostasis
  • regulates cytosolic zinc level, resulting in the enhancement of AKT1 and ERK phosphorylation
  • is a Zn2+ transporter, testosterone receptor, and mediator of signaling events through G-proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • enhance AKT1 and ERK1 and ERK2 phosphorylation in immune cells by regulating intracellular zinc concentration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion      
    PLEKHD1-SLC39A9 in schizophrenia
    tumoral       gain of function
    in malignant breast and prostate tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential therapeutic target for treating breast and prostate cancers
    cancerreproductiveprostate
    potential therapeutic target for treating breast and prostate cancers
    ANIMAL & CELL MODELS