Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC39A6 contributors: mct - updated : 12-11-2021
HGNC name solute carrier family 39 (zinc transporter), member 6
HGNC id 18607
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site motif of the zincin metalloproteases
  • two histidine-rich sequences
  • a HELP domain
  • HOMOLOGY
    interspecies ortholog to murine Slc39a6
    ortholog to rattus Slc39a6_predicted
    Homologene
    FAMILY
  • ZIP transporter (tc 2.a.5) family
  • KE4/catsup subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • would be involved in heavy metal ion transport
  • may be a suitable prognostic marker for lymph-node involvement and a key determinant of metastatic spread in steroid hormone receptor-positive disease
  • tumor-promoting role for SLC39A6 in ESCC
  • zinc entry into activated lymphocytes depends on SLC39A6 and this transporter is essential for the correct function of the cellular activation machinery
  • SLC39A10/SLC39A6 heteromer is essential for the zinc-mediated trigger of mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text may be a zinc transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by oestrogen treatment
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oestrogen-positive breast cancer with metastasis
    constitutional       gain of function
    strongly upregulated early during T cell activation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as an early detector of high-risk subjects and prognostic biomarker in Esophageal squamous cell carcinoma (ESCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    targeting of SLC39A6 might be a potential therapeutic strategy for blocking ESCC
    ANIMAL & CELL MODELS