| basic FUNCTION
| transforming growth factor, involved in mitogenesis and angiogenenesis |
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able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation |
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major autocrine EGF receptor ligand  |
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having an EGFR-independent action, in which it protects NKD2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells |
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influence risk of CL/P through unconventional means with an apparent parent-of-origin effect (excess maternal transmission) and possible interaction with maternal exposures |
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TGFA and EREG lead to complete receptor recycling, and AREG does not target EGFR for lysosomal degradation but causes fast as well as slow EGFR recycling |
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EGF and TGFA retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene |
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may attenuate hepatic fibrosis in part because of upregulation of the expression of MMP1 |
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MMP9 expression induced by TGFA is a valid target of PPARD ligands in keratinocytes |
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appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification |
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increased proliferation and migration of pancreatic stellate cells (PSCs), and TGFA-induced migration of cells may be partly due to upregulation of MMP1 |
