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FLASH GENE
Symbol SLC30A5 contributors: mct - updated : 06-02-2018
HGNC name solute carrier family 30 (zinc transporter), member 5
HGNC id 19089
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fifteen predicted membrane-spanning domains with extracellular N and C termini
  • between transmembrane domains 9 and 10, ZTL1 has a zinc-binding histidine-rich intracellular loop
  • HOMOLOGY
    interspecies homolog to rattus Slc30a5 (94.9 pc)
    homolog to murine Slc30a5 (95.4 pc)
    Homologene
    FAMILY
  • cation diffusion facilitator family of transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleolus
    text
  • endosomal vesicles
  • apical plasma membrane
  • basic FUNCTION
  • involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartmen
  • playing an important role for transporting zinc into secretory granules in pancreatic beta cells
  • required for contact hypersensitivity and mast cell-mediated delayed-type allergic response but not for immediate passive cutaneous anaphylaxis
  • selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation
  • might play an important role in regulated GH secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text
  • cellular zinc ion homeostasis
  • Zn2+ transport
  • regulation of proton transport
  • PATHWAY
    metabolism metal
    signaling
    a component heterodimerizing with SLC30A6 (cytosolic C-terminal tail of SLC30A5 is important in determining SLC30A6 as a partner molecule for heterodimer formation)
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    Other zinc-mediated transcriptional repression of the human SLC30A5 gene involves the zinc-dependent binding of a zinc-regulated protein factor to a palindromic sequence, the ZTRE, upstream of the end of the 5&
    8242;-UTR
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in milk zinc deficiency that are linked to low levels of the SLC30A5 and SLC30A6 zinc transporters
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • ZnT5-null mice presented with abnormal bone development and impaired growth compared to wild-type counterparts