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FLASH GENE
Symbol RAPGEF6 contributors: mct - updated : 06-04-2011
HGNC name Rap guanine nucleotide exchange factor (GEF) 6
HGNC id 20655
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PDZ domain, a cyclic nucleotide-binding domain
  • a RasGEF domain
  • an SH3 domain
  • PPDY motif at the C-terminus binding to the WW domain of BAG3
  • HOMOLOGY
    Homologene
    FAMILY multiple-member family of guanine nucleotide exchange factors (GEFs) for RAP1
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • promoting the exchange of RAS-bound GDP by GTP
  • specifically responsible for the activation of RAP1 that mediates tumor necrosis factor-alpha (TNF-alpha)-triggered integrin activation
  • crucial role of the cross-talk between two Ras-family GTPases MRAS and RAP1, mediated by RAPGEF6, in adhesion signaling
  • activates RAP1A and RAP1B to perform different functions and plays a critical role in the maturation of adherens junctions
  • critical partner for BAG3 in regulating cell adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerization facilitates formation of a complex with MLLT4 and PDZGEF2 that activates RAP1A, which regulates beta1 integrin levels and cell migration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically and functionally associated with the PDZ domain-containing MLLT4 and F11R, but not zonula occludens (ZO)-1, in epithelial cells
  • BAG3-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS