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FLASH GENE
Symbol RASSF6 contributors: mct/npt - updated : 06-06-2014
HGNC name Ras association (RalGDS/AF-6) domain family member 6
HGNC id 20796
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Sav/RASSF/Hippo (SARAH) domain (Ikeda 2007)
  • a C-terminal Ras-association (RA) domain that binds activated Ras (Allen 2007)
  • HOMOLOGY
    Homologene
    FAMILY RASSF family proteins
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play a role in dictating the degree of inflammatory response to the respiratory syncytial virus (Allen 2007)
  • demonstrates the properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members (Allen 2007)
  • implicated in apoptosis in HeLa cells and it triggers both caspase-dependent and caspase-independent pathways (Ikeda 2007)
  • may function as tumour suppressors by regulating the cell cycle and apoptosis (van der Weyden 2007)
  • caused apoptosis when released from activated STK3 in a manner dependent on WW45, the mammalian Salvador homolog (Ikeda 2009)
  • antagonizes Hippo signaling and mediates apoptosis through a pathway that is parallel to the canonical Hippo pathway (Ikeda 2009)
  • stabilizes TP53, regulates apoptosis and the cell cycle, and functions as a tumor suppressor
  • involved in TP53-mediated G1/S arrest
  • RASSF6 may play a tumor suppressor role in the progression of clear cell renal cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds RAS
  • bound to STK3 (RASSF6 inhibited STK3 activity to antagonize Hippo signaling) (Ikeda 2009)
  • binds MDM2 and facilitates its ubiquitination
  • RASSF6 triggers CDKN1A accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS