Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GIPC3 contributors: mct - updated : 24-08-2010
HGNC name GIPC PDZ domain containing family, member 3
HGNC id 18183
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central PDZ domain, which interact with Frizzled-3 (FZD3) class of WNT receptor, insulin-like growth factor-I (IGF1) receptor, receptor tyrosine kinase TrkA, TGF-beta type III receptor (TGF-beta RIII), integrin alpha6A subunit, transmembrane glycoprotein 5T4, and RGS19/RGS-GAIP (Katoh 2002)
  • GIPC homology (GH1 and GH2) domains
  • HOMOLOGY
    intraspecies homolog to GIPC1, GIPC2
    Homologene
    FAMILY
  • GIPC family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in g protein-linked signaling
  • might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion (Katoh 2002)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB72
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS