Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GBP5 contributors: mct - updated : 01-10-2014
HGNC name guanylate binding protein 5
HGNC id 19895
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal part, that carries the geranylgeranylation motif , C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins
  • HOMOLOGY
    Homologene
    FAMILY interferon-gamma-inducible large GTPases family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution
  • prenylated and prenylation is required for the membrane association
  • basic FUNCTION
  • may be involved in immune response and have cancer-related functions
  • GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner
  • promoted selective NLRP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents
  • serves as a unique rheostat for NLRP3 inflammasome activation and extends our understanding of the inflammasome complex beyond its core machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GBP5 promotes CASP1–mediated protection against oral Listeria infection and NLRP3-dependent inflammatory responses
  • cell & other
    REGULATION
    induced by robustly induced only by IFN-gamma and not by TNF-alpha and IL-1beta
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS