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FLASH GENE
Symbol UNC13B contributors: mct/npt/pgu - updated : 02-02-2017
HGNC name unc-13 homolog B (C. elegans)
HGNC id 12566
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal 100AA stretch
  • three C2 domains
  • a diacylglycerol-binding C1 domain, that interacts with phorbol ester or diacylglycerol (DAG) and phospholipid
  • HOMOLOGY
    interspecies homolog to C.elegans Unc13-like
    homolog to murine Unc13h1
    Homologene
    FAMILY
  • Munc13 family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text with DOC2A highly concentrated on synaptic vesicles and the presynaptic plasma membrane
    basic FUNCTION
  • promoting the priming of synaptic vesicles by acting through syntaxin
  • mediated vesicle priming not restricted to neurotransmitter release but is also functional in insulin secretion
  • playing a potential role in mediating some of the acute and chronic changes in MC produced by exposure to hyperglycemia
  • with DOC2B are implicated in Ca2+-dependent neurotransmitter release
  • RAB3IL1 and its binding partner UNC13B, and the subsequent gating of vesicle fusion by activation of the Ca2+ channels, are implicated in the docking of vesicles at the transmitter release site, a process of neurosecretion
  • having essential function in synaptic vesicle priming and in the modulation of synaptic strength, and key regulator of these adaptive mechanisms
  • essential regulator of synaptic vesicle priming and playing a key role in adaptive synaptic plasticity phenomena
  • RAB34 and its effector UNC13B constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
  • UNC13B and UNC13C limit the ability of UNC13A to regulate calcium-dependent replenishment of readily releasable pool and slow pool to fast pool conversion in central synapses
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • syntaxin
  • FMR1 (RNA target of FMR1)
  • UNC13B serves as an effector of RAB34, mediating lysosome-Golgi trafficking
  • DOC2B-UNC13B interactions are stimulated by phorbol ester through the C1 domain of UNC13B
  • interaction between DOC2A and UNC13B is required for Ca2+-dependent neurotransmitter release from intact neuron
  • interaction with CALM1
  • UNC13B and RAB34 interact at the Golgi via the munc13 homology domain 2 (MHD2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS