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FLASH GENE
Symbol POLR1B contributors: KTN/npt - updated : 07-01-2008
HGNC name polymerase (RNA) I polypeptide B, 128kDa
HGNC id 20454
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C4 type zinc finger
  • HOMOLOGY
    interspecies homolog to chimpanzee POLR1B (99.6 pc)
    homolog to rattus Rpo1-2 (90.8 pc)
    homolog to murine Rpo1-2 (89.7 pc)
    Homologene
    FAMILY
  • RNA polymerase beta chain family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • proposed to contribute to the polymerase catalytic activity and forming the polymerase active center together with the largest subunit
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
  • biosynthesis of rRNA
  • a component
  • component of the multisubunit complex of eukaryotic nuclear DNA directed RNA polymerase producing ribosomal RNA, brought to ribosomal genes as a distinct subunit
  • second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS