basic FUNCTION
| E3 ubiquitin ligases, which suppress transforming growth factor-beta (TGFB) family signaling through degradation of Smads and receptors for TGFB and bone morphogenetic proteins |
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act in the same direction as SMURF1 in TGFB family signaling but play opposite roles in cell migration |
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induces ubiquitin-dependent degradation of SMURF1 to prevent migration of breast cancer cells |
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involved in protein modification, ubiquitin cycle |
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plays critical roles in the regulation of transforming growth factor-beta (TGF-beta)-Smad signaling via ubiquitin-dependent degradation of SMAD2 and SMAD7 |
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important regulator of the TGF-beta signaling pathway, targeting TGF-beta receptors and various Smads for proteasome-mediated degradation |
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has a physiological role during embryo implantation, especially in trophoblast invasion, and this function may involve downregulation of TGF-beta type I receptor. |
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inducing degradation of GSK-3beta and upregulating beta-catenin in chondrocytes |
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important role for SMURF2 binding to TRAF2 in determining specific signalling outputs of TNFRSF1B |
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important regulator of TNFSF1B-mediated responses |
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promotes TP53 degradation by enhancing the activity of the E3 ligase MDM2 |
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functions as a factor to stabilize MDM2 protein rather than as a direct E3 ligase in regulation of TP53 degradation |
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enhances heterodimerization of the MDM2-MDM4 but inhibits homodimerization of MDM2 |
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plays a significant role in the pathomechanism of progressive supranuclear palsy by causing abnormal redistribution of neuronal nuclear SMAD2/3 to the cytoplasm |
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inducing multiple mono-ubiquitination of SMAD3 |
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negatively regulates TGFB signalling by attenuating the activity of SMAD3 rather than promoting its degradation |
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SMURF2, one of the Smad ubiquitin regulator factor proteins, is an important negative regulator of virus-triggered type I IFN signaling, which targets at the MAVS level |