Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HECTD1 contributors: mct - updated : 29-08-2018
HGNC name HECT domain containing 1
HGNC id 20157
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one HECT domain
  • HOMOLOGY
    Homologene
    FAMILY
  • UPL family
  • K-HECT subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • in trophoblast giant cells (TGCs) and other trophoblast-derived cell subtypes in the junctional and labyrinth zones of the placenta
  • basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • HECTD1 function is required at a critical threshold for neural tube closure
  • is a functional ubiquitin ligase
  • HECTD1 promotes the APC-AXIN1 interaction to negatively regulate WNT signaling
  • is required for development of multiple cell types within the junctional zone of the placenta
  • is involved in ABCA1-mediated cholesterol export from macrophages
  • control of MACF1 levels by HECTD1 modulates likely epithelial-to-mesenchymal transition (EMT) and the efficiency of metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrates of HSP90AA1
  • Condensins positively regulate ligand-dependent enhancer activation at least in part by recruiting HECTD1, to modulate the binding of enhancer-associated coactivators/corepressors, including NRIP1
  • regulates the protein level of IQGAP1 through ubiquitination and therefore mediates the dynamics of focal complexes (FXs) including the recruitment of paxillin and actinin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in mid-gestation lethality and intrauterine growth restriction (IUGR)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS