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FLASH GENE
Symbol ATG10 contributors: mct - updated : 31-03-2020
HGNC name ATG10 autophagy related 10 homolog (S. cerevisiae)
HGNC id 20315
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • autophagocytosis associated protein, C-terminal domain
  • importance of two sulfhydryl groups on Cys44 and Cys135 in ATG10 protein
    • secondary structure
  • mutation or loss of Cys44 or/and Cys135 made ATG10 steric conformational change toward a ATG10S-like structure, rather than old disulfide bonds were disrupted and new ones reformed, leading to the similar ATG10S functions
    • HOMOLOGY
    interspecies homolog to S cerevisiae autophagy 10
    Homologene
    FAMILY
  • ATG10 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • play an important role in the invasion and proliferation of cancer cells, and bacterial infections
  • might act as a latent transcription factor after losing its -SH group on Cys44 and/or Cys135
  • is essential for autophagy since it promotes ATG5-ATG12 complex formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text may be involved in ubiquitin cycle and protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • native ATG10 protein generally exists as an oligomer manner in the autophagy process
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATG10 interacts with ATG7 to receive an ubiquitin-like protein ATG12, recognizes both ATG12 and ATG5 directly and catalyzes their conjugation reaction
  • autophagic E2 enzymes, ATG10, interacts with ATG7 to receive ATG12, a ubiquitin-like molecule, and is also involved in the ATG12-ATG5 conjugation reaction
  • ATG10S as a transcription factor competes with IRF1 for the same binding site to promote IFNL2 gene transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to development of hepatocellular carcinoma (HCC)
  • to breast cancer
    • Variant & Polymorphism other
  • ATG10 rs1864183, ATG10 rs10514231 significantly associated with HCC risk
  • rs1864182 and rs10514231 in ATG10 were significantly associated with a decreased risk of breast cancer
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    ATG10S might be a new host factor against HCV replication, and is a target for screening chemicals with new anti-virus mechanisms
    ANIMAL & CELL MODELS