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FLASH GENE
Symbol APCDD1 contributors: mct - updated : 18-08-2010
HGNC name adenomatosis polyposis coli down-regulated 1
HGNC id 15718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential TCF4-binding sites
  • a transmembrane domain
  • conjugated GlycoP
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • can interact with WNT3A and LRP5 and may regulate a diversity of biological processes controlled by Wnt signaling (Shimomura 2010)
  • inhibits Wnt signalling in a cell-autonomous manner and functions upstream of beta-catenin (Shimomura 2010)
  • probably a membrane-tethered Wnt inhibitor that acts as a dimer at the surface of the Wnt-receiving cell (Shimomura 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ligands and receptors of the canonical Wnt pathway (Shimomura 2010)
  • cell & other
    REGULATION
    Other regulated by the beta-catenin/Tcf complex
    ASSOCIATED DISORDERS
    corresponding disease(s) HTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS