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FLASH GENE
Symbol ANKS1A contributors: mct/npt/pgu - updated : 06-04-2010
HGNC name ankyrin repeat and sterile alpha motif domain containing 1A
HGNC id 20961
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several ankyrin motifs
  • two sterile alpha motifs (SAM motif), that directly bind to ubiquitin, suggesting that Anks proteins regulate the degradation of ubiquitinated EphA receptors
  • a phosphotyrosine binding domain, not required for its tyrosine phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY
  • ankyrin repeat and sterile alpha motif domain-containing (Anks) protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be playing a negative role in growth factor receptor signaling pathways
  • cytosolic phosphotyrosine binding (PTB) domain containing negative regulatory protein, that could play a significant functional role to negatively regulate growth factor receptor signaling pathways
  • possible function for ANKS family proteins as scaffolding proteins of the EPHA8 signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component EPHA8 formed a ternary complex with both RINL and ANKS1A
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tyrosine phosphorylated upon addition of growth factors, such as EGF or PDGF, but not by cytokines, such as IL3 or erythropoietin
  • possible function for ANKS family proteins (ANKS1A, ANKS1B) as scaffolding proteins of the EPHA8 signaling pathway
  • more physiologically relevant partner of EPHA8 in mammalian cells, as ANKS1B
  • Src family kinase target in colorectal cancer cells
  • RINL interacts with odin, a member of the ankyrin-repeat and sterile-alpha motif (SAM) domain-containing (Anks) protein family
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS