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FLASH GENE
Symbol CREB3L4 contributors: mct - updated : 23-12-2013
HGNC name cAMP responsive element binding protein 3-like 4
HGNC id 18854
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal activation domain
  • a central bZIP domain
  • a predicted transmembrane domain
  • an adjacent cleavage site for the Golgi protease S1P, with conserved features which indicate that it represents a specific subclass of S1P sites
  • a C terminal transmembrane domain
  • HOMOLOGY
    interspecies ortholog to murine Creb3l4
    ortholog to rattus creb3l4
    Homologene
    FAMILY
  • BZIP family
  • CREB/ATF family transcription factor
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator
  • binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes BBF2
  • involved in regulation of transcription, DNA-dependent
  • may be playing an important role in prostate cancer and in androgen receptor signaling in prostate cells
  • probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of Hepatocellular carcinoma (Inagaki 2008)
  • ER-resident transmembrane transcription factor that is structurally similar to CREB3L1
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CREB3L4 and CREB3L1 may form a heterodimer that promotes the expression of target genes required for the differentiation of goblet cells
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved in a site-specific manner in response to brefeldin A disruption of the Golgi or by coexpression with S1P but only after deletion or substitution of its C-terminal lumenal domain
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by androgens in prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS