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FLASH GENE
Symbol AGTRAP contributors: SGE/npt - updated : 05-10-2009
HGNC name angiotensin II receptor-associated protein
HGNC id 13539
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Agtrap (75.5pc)
homolog to murine Agtrap (77.4pc)
Homologene
FAMILY
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • playing a role in the recycling of the AT(1) receptor to the plasma membrane with presumable concomitant recovery of receptor signal functions
  • negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation or by receptor desensitization such as phosphorylation
  • inducing also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity
  • downregulating AT1R and attenuating certain angiotensin II-mediated hypertrophic responses in cardiomyocytes (Tanaka 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1
  • interaction with CAMLG may mediate the AGT actions in vascular physiology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS