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FLASH GENE
Symbol GPSM1 contributors: mlc/npt - updated : 04-01-2008
HGNC name G-protein signalling modulator 1 (AGS3-like, C. elegans)
HGNC id 17858
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal seven tetratricopeptide repeats (the TPR domain), a mediator of protein-protein interaction
  • one WH1 domain
  • WH2 domain
  • C-terminal four G protein regulatory motifs [the GPR or GoLoco domain, a modulator of G protein signaling
  • HOMOLOGY
    interspecies ortholog to murine Gpsm1
    ortholog to rattus Ags3
    Homologene
    FAMILY
  • GPSM family
  • CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • having GTPase activator activity, and involved in signal transduction
  • playing a critical role in drug addiction
  • involved in an early event during the autophagic pathway probably prior to the formation of the autophagosome
  • playing a potential role in the formation or maintenance of neural plasticity
  • modulating the protein trafficking along the transgolgi/network/plasma membrane/endosome loop
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS