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FLASH GENE
Symbol ADIPOR1 contributors: mct - updated : 25-02-2013
HGNC name adiponectin receptor 1
HGNC id 24040
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal cytoplasmic domain interacted with APPL (adaptor protein containing pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif
  • seven transmembrane domains that are different from classical G-protein-coupled receptors in structure and function
  • C-terminal extracellular domain interacted with adiponectin
  • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies homolog to murine Adipor1 (96.8pc)
    homolog to rattus Adipor1 (97.6pc)
    Homologene
    FAMILY
  • ADIPOR family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • constitutively expressed on the cell-surface
  • basic FUNCTION
  • enhancing the binding of both globular and full-length adiponectin
  • major adiponectin receptors, which mediate the major, if not the entire, part of adiponectin binding and adiponectin actions
  • critical transcription factor that controls and upregulates the enzymes involved in fatty acid synthesis such as fatty acid synthase (FAS) and acetyl-CoA carboxylase ACC1 in the liver
  • involved with ADIPOQ in the regulation of PGC1A and mitochondria by Ca2+
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TXNDC5 interacts specifically with ADIPOR1, providing evidence that TXNDC5 modulates adiponectin signalling
  • ATF3 interacts directly with its promoter
  • interaction partner of CSNK2B (interaction of ADIPOR1 with the tetrameric complex and CSNK2B is as a key player in adiponectin signaling)
  • cell & other
    REGULATION
    repressed by FOXO1 (implicated in the negative regulation of ADIPOR1 promoter by insulin)
    Other modulated by PPAR and LXR ligands
    negatively regulated by ATF3 in insulin-sensitive cells and insulin secreting cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic lesions
    constitutional     --low  
    in obesity playing causal roles, at least in part, in the development of insulin resistance and diabetes
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
  • decreased level of ADIPOR1 (and ADIPOQ) in obesity may have causal roles in mitochondrial dysfunction and insulin resistance seen in diabetes
  • Marker
    Therapy target
    ANIMAL & CELL MODELS