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FLASH GENE
Symbol UCN3 contributors: SGE/npt - updated : 19-03-2010
HGNC name urocortin 3 (stresscopin)
HGNC id 17781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide for secretion
  • the predicted mature region flanked by potential proteolytic cleavage sites
  • an alpha-amidation donor residue
  • HOMOLOGY
    Homologene
    FAMILY
  • sauvagine/corticotropin-releasing factor/urotensin I family
  • corticotrophin-releasing hormone (CRH) family of peptides
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be representing endogenous ligand for maintaining homeostasis after stress
  • in the brain, may be responsible for the effects of stress on appetite
  • suppresses food intake, delays gastric emptying and decreases heart-induced edema
  • may inhibit progesterone production through interaction with CRHR2 (Yata 2009)
  • may act as an autocrine or paracrine regulator in normal adrenal and adrenal tumors (Takahashi 2006)
  • playing some physiological or pathologic roles in the modulation of gastro intestinal functions during stressful conditions (Saruta 2005)
  • novel role for UCN3 and CRHR2 related to the processing of social cues and to the establishment of social memories
  • may regulate the cardiac and renal functions as a local factor and a circulating hormone (Takahashi 2004)
  • possible involvement of UCN2 and UCN3 in the mechanisms of endometriosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in preeclamptic (PE) placentae, the increased expression of UCN2, UCN3 may reflect a response to the oxidative stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS