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FLASH GENE
Symbol NSF contributors: - updated : 18-07-2006
HGNC name N-ethylmaleimide-sensitive factor
HGNC id 8016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two AAA family chaperone-like (adenosine triphosphatases associated with diverse cellular activities),
  • RNA helicase domain
    • mono polymer homomer , hexamer
    HOMOLOGY
    interspecies homolog to murine Nsf
    Homologene
    FAMILY AAA family of ATPases
    CATEGORY chaperone/stress , enzyme , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in membrane fusion by hydrolysis ATP and subsequent dissociation of SNARE complex
  • recruited to the synaptic core (SNARE) complex at the site of fusion with NAPA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-SNAP (SNAPA)
  • VAMP8
  • RAB-GTPase,STX7
  • RABGA,RAB3,RAB4
    • cell & other
    REGULATION
    activated by RAB3 and RAB4
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS