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FLASH GENE
Symbol NKAPL contributors: mct - updated : 04-04-2022
HGNC name NFKB activating protein-like
HGNC id 21584
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • germ cell-specific transcriptional suppressor in Notch signaling
  • is indispensable because aberrantly elevated NOTCH signaling has negative effects on spermatogenesis, affecting spermatogonial stem cell (SSC) maintenance and differentiation factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NOTCH signaling should be properly regulated through the transcriptional factor NKAPL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other
  • rs1635 in the NKAPL gene appeared to play a role in conferring susceptibility to schizophrenia
  • Candidate gene
    Marker
  • potential diagnostic and prognostic markers in triple-negative breast cancer
  • methylation of NKAPL is a frequent event and is a potential prognosis biomarker in Hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Nkapl-deleted mice showed complete arrest at the level of pachytene spermatocytes