basic FUNCTION
| binding of mRNA cap structure to ribosome 43S |
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increasing the poly (A)-binding protein (PABPx) RNA binding activity |
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controlling expression of genes in the retinoic pathway of cellular differentiation |
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polysome associated in proliferating cells and moves to stress granules in stressed, nonapoptotic cells that can activate translation independent of caspase cleavage |
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functions as a scaffold protein promoting cap-independent translation of proteins |
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crucial for continuous cell survival in nonstressed cells |
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having a necessary role for maintaining cell survival during mitosis by promoting cap-independent translation of at least two prosurvival proteins BCL2 and CDK1 |
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EIF4G1 clearly has specific functions that do not overlap that of EIF4G2 |
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EIF4G2-mediated translation of a specific set of proteins is critical for the transition from pluripotency to differentiation, highlighting the importance of cap-independent translation in stem cell fate decisions |
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is involved in the translation of proteins that are required for cell differentiation |