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FLASH GENE
Symbol AKIRIN2 contributors: mct - updated : 27-01-2015
HGNC name akirin 2
HGNC id 21407
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • akirin family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • conserved nuclear factor required for innate immune responses
  • promotes sustained ERK1/2 activation through repression of MAKP1 transcription, resulting in promotion of tumorigenicity and metastasis
  • plays an important role in oncogenesis of LLC1 lung carcinoma cells, an may also serve as an oncogene in other cancers
  • important nuclear factor which plays functions in innate immune response, myogenesis, muscle development, and carcinogenesis
  • nuclear protein, bridging NFKB1 and the chromatin remodeling SWI/SNF complex by interacting with SMARCD proteins as well as NFKBIZ, which forms a complex with the NFKB1 p50 subunit
  • is critical for inducing inflammatory genes by bridging NFKBIZ and the SWI/SNF complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • AKIRIN2-YWHAB complex could act as a transcriptional silencer, and MAPK1 was one of the target genes of the AKIRIN2-YWHAB complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YWHAB-binding factor
  • BCAM is a suppressive oncoprotein, and FBI1/AKIRIN2 is involved in tumorigenicity and metastasis of hepatoma through the downregulation of suppressive oncogenes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    inhibited tumorigenicity and metastasis accompanying a decrease in MMP9 (matrix metalloproteinase-9) expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS