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FLASH GENE
Symbol AP2S1 contributors: - updated : 18-07-2006
HGNC name adaptor-related protein complex 2, sigma 1 subunit
HGNC id 565
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY clathrin adaptor complexes small chain proteins family
CATEGORY adaptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,vesicle
text cytoplasmic face of coated vesicles
basic FUNCTION component of the adaptor complexes which link clathrin to receptors in coated vesicles
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • small chain component of the major clathrin adaptor complex AP2
  • heterotetramer composed of two large adaptins
  • (alpha1A/AP2A1 or alpha1B/AP2A1 or alpha2/AP2A2 and beta1/AP2B1), a medium adaptin (mu2/AP2M1) and
    a small adaptin (sigma2long/AP2S1 or sigma2short/AP2S1)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS