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FLASH GENE
Symbol KCNJ12 contributors: mct - updated : 27-10-2012
HGNC name potassium inwardly-rectifying channel, subfamily J, member 12
HGNC id 6258
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore,including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel subfamily J
  • inward rectifier-type potassium channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • participating in establishing action potential waveform and excitability of neuronal and muscle tissues
  • KCNJ2 and KCNJ12 are primary determinants of endogenous K(+) conductance in aortic endothelial cells under resting conditions and KCNJ12 provides the dominant conductance in these cells
  • KCNJ2 and KCNJ12 have two distinct lipid requirements for activity: a specific requirement for INPP5J and a nonspecific requirement for anionic phospholipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EDN1 inhibits human cardiac I(K1) current via a PKC-mediated phosphorylation of KCNJ12 channel subunits and additional regulatory effects on KCNJ4 channels
  • binding to INPP5J
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PPKCA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS