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FLASH GENE
Symbol NUBPL contributors: mct - updated : 29-04-2013
HGNC name nucleotide binding protein-like
HGNC id 20278
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nubpl (84.5pc)
homolog to rattus Nubpl (88.1pc)
Homologene
FAMILY
  • MRP/NBP35 ATP-binding proteins family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • required for biogenesis and export of both ribosomal subunits
  • critically required for the assembly of the respiratory complex I (NADH:ubiquinone oxidorecutase), with a possible role in the delivery of one or more Fe/S clusters to complex I subunits
  • mitochondrial P-loop NTPase
  • assembly factor for complex I
  • essential for the incorporation of Fe/S clusters into complex I subunits
  • involved in assembly of iron-sulfur clusters early in the complex I assembly pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP binding
  • can bind an Fe/S cluster via a conserved CXXC motif in a labile fashion (Sheftel 2009)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEIO2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS