Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AHNAK2 contributors: mct - updated : 13-04-2016
HGNC name AHNAK nucleoprotein 2
HGNC id 20125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain funtioning as a PDZ domain, PDZ domain structure containing a bound class III ligand peptide
  • heptad repeat motifs similar to antiparallel beta-strands found in beta propeller proteins
  • HOMOLOGY
    Homologene
    FAMILY giant propeller-like proteins family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    basic FUNCTION
  • may be involved in regulating excitation/contraction coupling of cardiomyocytes
  • is an important element of the FGF1 nonclassical export pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • tight homodimerization may be central to the scaffolding functions of PRX and AHNAK2 in molecular complexes linking the extracellular matrix to the cytoskeletal network
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with L-type cacium channels
  • in heat-shocked cells, FGF1 and the C-terminal fragment of AHNAK2 colocalized with F-actin in the vicinity of the cell membrane
  • cell & other
    REGULATION
    Other phosphorylated by protein kinase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS