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FLASH GENE
Symbol USF1 contributors: mct/npt/pgu - updated : 04-10-2016
HGNC name upstream transcription factor 1
HGNC id 12593
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding protein with helix-loop-helix (HLH)
  • leucine zipper domain
  • a core motif, CACGTG, termed E box
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Usf1
    Homologene
    FAMILY
  • basic helix-loop-helix leucine zipper family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription factor binded to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters
  • regulating several genes of lipid and glucose homeostasis
  • recruits histone modification complexes and is critical for maintenance of a chromatin barrier
  • serve as modulators in the induction of OSCAR and TNFSF11-mediated osteoclastogenesis
  • activate the hepatic lipase promoter via E-box dependent and independent mechanisms
  • USF1 and NFE2 together regulate the association of Pol II with the adult beta-globin gene promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • USF1, PRMT1, and the histone acetyltransferases (HATs) KAT2B form a complex with both H4R3 histone methyltransferase and HAT activities
  • INTERACTION
    DNA binding to the AP-1/AP-4 site on the APP promoter
    RNA
    small molecule
    protein
  • physical association between USF1 and GATA1
  • interacts directly with the histone H4R3-specific methyltransferase PRMT1
  • interaction with FADS3 (FADS3 expression is modulated by USF1)
  • interact with and repress functional activities of key transcription factors involved in cellular differentiation, including USF1
  • USF1 interacts with NFE2 in erythroid cells
  • repression of USF1 transcriptional activity by HDAC9 could disrupt adipogenic differentiation
  • PDX1 contributes to the transcriptional transactivation of ALX3 in pancreatic beta-cells by acting in co-ordination with USF1 and USF2 (pMID: 25040025)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FCHL1
    Susceptibility
  • to diabetes and atherosclerosis
  • to male infertility with non-obstruction azoospermia (NOA)
  • Variant & Polymorphism SNP
  • intronic SNP increasing the risk of diabetes and atherosclerosis (in association with APOE mutations)
  • variant rs2516838 of USF1 was associated with NOA susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS