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FLASH GENE
Symbol IGHV1-46 contributors: - updated : 28-10-2005
HGNC name immunoglobulin heavy variable 1-46
HGNC id 5554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond, made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence, the remaining part being relatively constant and forming the framework
HOMOLOGY
Homologene
FAMILY Immunoglobulin superfamily
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION forming the antigen binding site together with the cognate region of the light chain
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS immunity/defense
text humoral immunity, antibody synthesis
PATHWAY
metabolism
signaling
Component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
a component
INTERACTION
DNA
RNA
small molecule
protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2). During the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • Bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS