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FLASH GENE
Symbol HECW2 contributors: SGE/npt - updated : 05-01-2010
HGNC name HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HGNC id 29853
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C2 domain at its NH(2)-terminus
  • two WW domains
  • one HECT domain at its COOH-terminus
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Hecw2 (95.2pc)
    homolog to rattus Hecw2 (94.7pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in protein modification, ubiquitin cycle
  • E3 ubiquitin-protein ligase that mediates ubiquitination of TP73, to stabilize TP73 and enhance activation of transcription by TP73
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP73
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS