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FLASH GENE
Symbol USF2 contributors: mct - updated : 15-11-2010
HGNC name upstream transcription factor 2, c-fos interacting
HGNC id 12594
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-loop-helix (HLH), leucine zipper protein
  • HOMOLOGY
    interspecies homolog to murine Usf2
    Homologene
    FAMILY
  • basix helix loop helix (bhlh) family of transcription factors
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription factor binded to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters
  • regulating expression of cathepsin B by binding to the E box element in the cathepsin B promoter as a repressor
  • serve as modulators in the induction of OSCAR and TNFSF11-mediated osteoclastogenesis
  • implicated in the progression of biliary atresia by regulation of hepcidin expression
  • activate the hepatic lipase promoter via E-box dependent and independent mechanisms
  • E-box-binding transcription factor of the basic-helix-loop-helix-leucine-zipper family, that binds to a consensus DNA sequence similar to FOXA1
  • mediates glucose-induced thrombospondin 1 expression and transforming growth factor-beta activity in mesangial cells and plays a role in diabetic nephropathy
  • one of the transcription factors that can regulate adiponutrin (PNPLA3) promoter activity in the presence of glucose
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the components of the FOXA1/androgen receptor transcriptional protein complex that contributes to the expression of androgen-regulated and prostate-specific genes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • c-fos interacting
  • binding of USF2 to prostate-specific gene promoters including the probasin promoter, spermine-binding protein promoter, and prostate-specific antigen core enhancer
  • PDX1 contributes to the transcriptional transactivation of ALX3 in pancreatic beta-cells by acting in co-ordination with USF1 and USF2 (pMID: 25040025)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    dirupted in t(6;19) with multicystic renal dysplasia (see also PUJO)
    Susceptibility to biliary atresia (BA)
    Variant & Polymorphism SNP
  • C and CC allele frequencies of rs916145 of USF2 were significantly higher in patients with BA than in healthy controls
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS