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FLASH GENE
Symbol TRAF3IP1 contributors: mct - updated : 30-08-2017
HGNC name TNF receptor-associated factor 3 interacting protein 1
HGNC id 17861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal calponin homology (CH) domain of IFT54 interacts with tubulins/MTs and has been proposed to transport tubulin during ciliogenesis
  • C-terminal coiled-coil domain, required for ubiquitination and proteasome-mediated degradation of TRAF3IP1 protein , that binds IFT20
    • whereas the C-terminal coiled-coil (CC) domain
    HOMOLOGY
    interspecies ortholog to C-Elegans DYF-11
    Homologene
    FAMILY
  • TRAF3IP1 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text localizes to cilia in the MDCK renal epithelial cells
    basic FUNCTION
  • required for sensory cilia formation
  • potential role in regulation of cytoskeleton dynamics in cells
  • TAF3IP1 function is highly conserved in ciliogenesis and is important for proper regulation of a number of essential developmental and cellular pathways
  • unexpected role of TRAF3IP1 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel conserved component of the IFT complex
  • intraflagellar transport proteins IFT172, IFT80, IFT57, TRAF3IP1, CLUAP1, and IFT20 form a stable tubulin-binding IFT-B2 complex
  • subunit of the IFT-B complex required for ciliogenesis
  • component of the IFT-B complex and is also associated with cytoplasmic microtubules (MTs)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibitor of IL13 signaling
  • DISC1
  • complete loss of IFT54 or the CC domain destabilizes IFT20
    • cell & other
  • interaction with both actin filaments and microtubule suggesting that it may play an important role in regulation of cytoskeleton dynamics in cells
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Traf3ip1 mutant mouse cells are unable to form cilia