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FLASH GENE
Symbol DDX43 contributors: mct - updated : 15-10-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
HGNC id 18677
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/DEAH (Asp-Glu-Ala-Asp/His) box helicase
  • nine conserved motifs grouped into two domains connected by a polylinker SAT region
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX5/DDX17 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • ATP-dependent RNA helicase displaying tumor-specific expression
  • implicated in the promotion of tumor growth in melanoma through RAS/AKT and RAS/ERK pathways
  • promotes proliferation and tumor growth of malignant melanoma cells
  • promotes tumor cell proliferation by regulating RAS protein expression, which in turn leads to the activation of downstream signaling pathways implicated in cell proliferation and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may promote NRAS protein expression by unwinding and stabilizing NRAS mRNA, therefore enhancing its translation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    by promoter hypomethylation and DDX43 hypomethylation may be a favorable prognostic factor in acute myeloid leukemia
    tumoral     --over  
    hypomethylation of the DDX43 promoter directly correlates with its expression in both CML cell lines and patients and is associated with advanced disease and poor outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    cancer therapies targeting DDX43 helicase may have broad applications for treating malignant melanoma
    ANIMAL & CELL MODELS