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FLASH GENE
Symbol DDX23 contributors: mct/npt - updated : 01-07-2010
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
HGNC id 17347
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Prp28
    homolog to murine Ddx23 (98.7pc)
    homolog to rattus Ddx23 (98.7pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX23/PRP28 subfamily
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having helicase, ATP binding, ATP dependent helicase activities
  • having function in spliceosome assembly (Mathew 2008)
  • may facilitate conformational changes in the spliceosome during pre-mRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome component required for splicing of nuclear pre-mRNA
  • component of the U5 snRNp complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein interaction with SRPK2 (role for SRPK2 in splicing and in spliceosome assembly) (Mathew 2008)
    cell & other
    REGULATION
    Other phosphorylation is required for its spliceosomal B complex association (Gustafson 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS