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FLASH GENE
Symbol FRS3 contributors: mct/npt - updated : 02-10-2018
HGNC name fibroblast growth factor receptor substrate 3
HGNC id 16970
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal myristylation sites for localization to membranes, including the plasma membrane
  • a phosphotyrosine binding (PTB) domain for binding to RTKs, such as the fibroblast growth factor (FGF) receptor and neurotrophin receptor (Minegishi 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • DOK family
  • fibroblast growth factor receptor substrate (FRS)-2 family proteins
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • docking proteins interacting with receptor tyrosine kinases and mediating particular biological responses
  • may be playing a role in the intracellular degradation systems of neural cells, which involves lysosomes (Minegishi 2009)
  • unique scaffolding adaptor that serves as a negative as well as a positive regulator for RTK signaling, depending on the receptor species (Minegishi 2009)
  • probable role of FRS3 in the intracellular degradation systems of neural cells, which involves lysosomes
  • FRS2, FRS3 may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RASA1, TEK receptor and EGF receptor
  • binds all neurotrophin TRK receptor tyrosine kinases and becomes tyrosine phosphorylated in response to NGF, BDNF, NT-3
  • binding GRB2 and SHP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS