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FLASH GENE
Symbol ATP2A3 contributors: mct/pgu - updated : 30-11-2011
HGNC name ATPase, Ca++ transporting, ubiquitous
HGNC id 813
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane coiled coil helices
  • four of which containing Ca2+ binding sites
  • a cytoplasmic beta strand between TM2/3,l
  • a phosphorylation and ATP binding globular domains (the latter linked to stalk sector 5) between TM4/5
  • HOMOLOGY
    Homologene
    FAMILY
  • P-type cation pump family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text sarco/endoplamic membrane nuclear envelop isoform ATP2A3
    basic FUNCTION
  • mediating the extrusion of CA2+ from internal stores in the endoplasmic reticulum
  • sarco/endoplasmic reticulum Ca2+ pump (role in cellular calcium signaling)
  • with ATP2A2, modulate thrombin-stimulated SOCE (store-operated Ca(2+)entry) probably by direct interaction with the TRPC1 channel inplatelets
  • low Ca2+-affinity ATP2A3, and the high Ca2+-affinity ATP2A2 enzymes are simultaneously expressed in B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STIM2 associates with ORAI1 and ATP2A3 upon discharge of the acidic Ca2+ stores in human platelets
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    functional remodelling of ER calcium homeostasis by down-regulation of SERCA3 expression constitutes a previously unknown mechanism involved in EBV-induced B cell immortalisation (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS